SOX21

From Wikipedia, the free encyclopedia

SRY (sex determining region Y)-box 21

PDB rendering based on 1gt0.

Available structures: 1gt0, 1o4x

Identifiers

Symbol(s)

SOX21; SOX25

External IDs

OMIM: 604974 MGI: 2654070 HomoloGene: 5143

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• establishment and/or maintenance of chromatin architecture • transcription • regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007084 (mRNA)
NP_009015 (protein)

XM_979432 (mRNA)
XP_984526 (protein)

Location

Chr 13: 94.16 - 94.16 Mb

Chr 14: 117.12 - 117.12 Mb

Pubmed search

[1]

[2]

SRY (sex determining region Y)-box 21, also known as SOX21, is a human gene.^[1]

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SOX21 SRY (sex determining region Y)-box 21.

[edit] Further reading

Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167-70. PMID 12194848.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Malas S, Duthie S, Deloukas P, Episkopou V (1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3.". Mamm. Genome 10 (9): 934-7. PMID 10441749.
Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.". FEBS Lett. 438 (3): 311-4. PMID 9827568.
Stevanović M, Lovell-Badge R, Collignon J, Goodfellow PN (1994). "SOX3 is an X-linked gene related to SRY.". Hum. Mol. Genet. 2 (12): 2013-8. PMID 8111369.
Denny P, Swift S, Brand N, et al. (1992). "A conserved family of genes related to the testis determining gene, SRY.". Nucleic Acids Res. 20 (11): 2887. PMID 1614875.