SOX12

From Wikipedia, the free encyclopedia

SRY (sex determining region Y)-box 12

Identifiers

External IDs

OMIM: 601947 MGI: 98360 HomoloGene: 5057

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006943 (mRNA)
NP_008874 (protein)

XM_973626 (mRNA)
XP_978720 (protein)

Location

Chr 20: 0.25 - 0.26 Mb

Chr 2: 152.09 - 152.09 Mb

Pubmed search

[1]

[2]

SRY (sex determining region Y)-box 12, also known as SOX12, is a human gene.^[1]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.^[1]

[edit] References

^ ^a ^b Entrez Gene: SOX12 SRY (sex determining region Y)-box 12.

[edit] Further reading

Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239-55. doi:10.1006/dbio.2000.9883. PMID 11071752.
Weiss MA (2001). "Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition.". Mol. Endocrinol. 15 (3): 353-62. PMID 11222737.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3-174. PMID 7566098.
Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes.". Nucleic Acids Res. 21 (12): 2943. PMID 8332506.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Jay P, Sahly I, Gozé C, et al. (1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.". Hum. Mol. Genet. 6 (7): 1069-77. PMID 9215677.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.