South Carolina Highway 261

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South Carolina Highway 261 is a state highway in the U.S. state of South Carolina. It runs 117.4 miles between Kershaw County to Yauhannah in Georgetown County.

Three U.S. National Historic Landmark, the Millford Plantation, Borough House Plantation and Church of the Holy Cross, are located on the highway in the High Hills of Santee region of Sumter County.