SORBS2

From Wikipedia, the free encyclopedia

Sorbin and SH3 domain containing 2

Identifiers

SORBS2; ARGBP2; KIAA0777; PRO0618

External IDs

Gene ontology
Molecular Function:	• nucleic acid binding • structural constituent of cytoskeleton • protein binding • cytoskeletal adaptor activity • zinc ion binding • structural constituent of muscle
Cellular Component:	• intracellular • nucleus • actin cytoskeleton • Z disc
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003603 (mRNA)
NP_003594 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 4: 186.74 - 187.11 Mb

n/a

Pubmed search

[1]

n/a

Sorbin and SH3 domain containing 2, also known as SORBS2, is a human gene.^[1]

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: SORBS2 sorbin and SH3 domain containing 2.

[edit] Further reading

Kioka N (2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku 74 (11): 1356-60. PMID 12510380.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.
Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.". J. Biol. Chem. 272 (28): 17542-50. PMID 9211900.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277-86. PMID 9872452.
Kawabe H, Hata Y, Takeuchi M, et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP).". J. Biol. Chem. 274 (43): 30914-8. PMID 10521485.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.". J. Mol. Biol. 307 (5): 1329-39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098-103. doi:10.1073/pnas.151252898. PMID 11481476.
Xu YC, Wu RF, Gu Y, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.". J. Biol. Chem. 277 (31): 28051-7. doi:10.1074/jbc.M202665200. PMID 12023963.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Soubeyran P, Barac A, Szymkiewicz I, Dikic I (2003). "Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.". Biochem. J. 370 (Pt 1): 29-34. doi:10.1042/BJ20021539. PMID 12475393.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.". J. Cell. Sci. 117 (Pt 12): 2557-68. doi:10.1242/jcs.01148. PMID 15128873.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.