SORBS1

From Wikipedia, the free encyclopedia

Sorbin and SH3 domain containing 1

PDB rendering based on 2dl3.

Available structures: 2dl3

Identifiers

Symbol(s)

SORBS1; CAP; DKFZp451C066; DKFZp586P1422; FLAF2; FLJ12406; KIAA1296; R85FL; SH3D5; SH3P12; SORB1

External IDs

OMIM: 605264 MGI: 700014 HomoloGene: 83252

Gene ontology
Molecular Function:	• actin binding • insulin receptor binding • protein kinase binding
Cellular Component:	• stress fiber • nucleus • zonula adherens • cell-substrate adherens junction • membrane • lipid raft
Biological Process:	• transport • insulin receptor signaling pathway • glucose transport • stress fiber formation • focal adhesion formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001034954 (mRNA)
NP_001030126 (protein)

NM_001034962 (mRNA)
NP_001030134 (protein)

Location

Chr 10: 97.06 - 97.31 Mb

Chr 19: 40.35 - 40.45 Mb

Pubmed search

[1]

[2]

Sorbin and SH3 domain containing 1, also known as SORBS1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SORBS1 sorbin and SH3 domain containing 1.

[edit] Further reading

Kioka N (2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku 74 (11): 1356–60. PMID 12510380.
Ribon V, Herrera R, Kay BK, Saltiel AR (1998). "A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.". J. Biol. Chem. 273 (7): 4073–80. PMID 9461600.
Mandai K, Nakanishi H, Satoh A, et al. (1999). "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions.". J. Cell Biol. 144 (5): 1001–17. PMID 10085297.
Asakura T, Nakanishi H, Sakisaka T, et al. (2000). "Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells.". Genes Cells 4 (10): 573–81. PMID 10583506.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport.". Nature 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Lebre AS, Jamot L, Takahashi J, et al. (2001). "Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions.". Hum. Mol. Genet. 10 (11): 1201–13. PMID 11371513.
Lin WH, Huang CJ, Liu MW, et al. (2001). "Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.". Genomics 74 (1): 12–20. doi:10.1006/geno.2001.6541. PMID 11374898.
Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMID 11481476.
Lin WH, Chiu KC, Chang HM, et al. (2002). "Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes.". Hum. Mol. Genet. 10 (17): 1753–60. PMID 11532984.
Cowan CA, Henkemeyer M (2001). "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.". Nature 413 (6852): 174–9. doi:10.1038/35093123. PMID 11557983.
Liu J, Kimura A, Baumann CA, Saltiel AR (2002). "APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.". Mol. Cell. Biol. 22 (11): 3599–609. PMID 11997497.
Xie J, Cai T, Zhang H, et al. (2003). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.". Genomics 80 (1): 54–61. PMID 12079283.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Vandenbroere I, Paternotte N, Dumont JE, et al. (2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.". Biochem. Biophys. Res. Commun. 300 (2): 494–500. PMID 12504111.
Yang WS, Lee WJ, Huang KC, et al. (2003). "mRNA levels of the insulin-signaling molecule SORBS1 in the adipose depots of nondiabetic women.". Obes. Res. 11 (4): 586–90. PMID 12690089.