Sophora flavescens
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| Sophora flavescens Aiton |
Sophora flavescens is a species of plant in the genus Sophora. Ku shen (the root)[1] or kushenin (a flavonoid compound) is a typical traditional Chinese medicine[2] that is found in this plant. It is commonly used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage[3] and skin diseases (such as colpitis, psoriasis and eczema). Its roots contain quinolizidine alkaloids, includying matrine (CAS-Number 519-02-8) and its oxide,[4] that interfere TNF-alpha and IL-6, suggesting that oxymatrine may inhibit the expression of the above pro-inflammatory cytokines.[5] Matrine also inhibited expression of Substance P and NK-1R in a human model of skin inflammation,[6] as well as acting as an agonist at mu and kappa opioid receptors.[7][8]
[edit] Notes
- ^ You-Ping Zhu 1998 Chinese Materia Medica - Chemistry, Pharmacology and Applications ISBN 9057022850
- ^ Schwarte A 2002 Phytochemische und pharmakologische Untersuchungen der Wurzeln von Sophora flavescens,unter besonderer Berücksichtigung ihrer Wirkung auf die Leukotrien- und Prostaglandinbiosynthese
- ^ Yamazaki M.2000. The pharmacological studies on matrine and oxymatrine. Yakugaku Zasshi 120(10) 1025-1033Abtracts
- ^ Yoshikawa et al (1985) Chem. Pharm. Bull. 33, 4267.
- ^ Ping Zheng, Feng-Li Niu, Wen-Zhong Liu, Yao Shi, Lun-Gen Lu 2005. Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats World Gastroenterology 11,4012
- ^ Liu JY, Hu JH, Zhu QG, Li FQ, Wang J, Sun HJ. Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts. International Immunopharmacology. 2007 Jun;7(6):816-23. PMID 17466915
- ^ Xiao P, Kubo H, Ohsawa M, Higashiyama K, Nagase H, Yan YN, Li JS, Kamei J, Ohmiya S. kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice. Planta Medica. 1999 Apr;65(3):230-3. PMID 10232067
- ^ Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, Narita M, Suzuki T. Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects. Biological and Pharmaceutical Bulletin. 2005 May;28(5):845-8. PMID 15863891
[edit] References
- Terada, M.; Sano, M.; Ishii, A.I. et al. - Studies on chemotherapy of parasitic helminths. (IV). Effects of alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated host tissues. Nippon Yakurigaku Zasshi, 79: 105-111, 1982.
- medicinal plants in the Republic of Korea
- [1]
