Talk:Sonic hedgehog
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[edit] Therapeutic relevance
I snipped the following section because I fail to see how it adds anything of value to the article. Perhaps with some more context, preferably in prose form, this would be more useful, but as a standalone list, it's hardly of benefit. Folks likely to be interested in such studies are most likely fully capable of typing "sonic hedgehog" into their friendly neighborhood PubMed search box. --David Iberri | Talk 22:44, 20 September 2005 (UTC)
*Cancers related to Hh signaling (antagonist)
-ameloblastoma
-oral squamous cell carcinoma
-gastric adenocarcinomas
-pancreatic cancer
-colorectal carcinoma
-Basal Cell Carcinomas
-Medulloblastoma
-Prostate Cancer
-Lung Cancer
-Multiple Exostoses
-rhabdomyosarcoma
Agonist uses of Hh signal
-Alopecia (hair loss)
*Adult stem cell linage specification and division
*Embryonic stem cell linage specification and division
Dopamine Neruons
Motor Neurons
Yes there are a lot of antagonist of the pathway that bind to the SMO. Cyclopamine being the most famous. This was my "dump" if you call it that. It is actually part of a bigger project for a database related to the Hh pathway. I have selected various studies that deal specifically with Hh signaling and that cancer. There is a lot of value. Just take a look at the implications. Embryonic stem cells, cancer, and even hair growth. Genentech is already in phase 1 trials for a Hh antagonist for BCC.
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- I don't think anyone was debating the importance of the Hedgehog pathway; and it's roles are definitely interesting - just that it was kind of a meaningless list. The information contained is interesting - but perhaps consider presenting the information as prose, rather than copying and pasting a list from your notes? It's an encyclopaedia, not a research forum. Confuseddave 21:32, 23 January 2006 (UTC)
[edit] Three Homologues?
Hey... my understanding is somewhat hazy, but I thought Sonic Hedgehog, Desert Hedgehog, and Indian Hedgehog were orthologues of the original Hedgehog identified in drosophila? The current edition is very unclear, and appears to imply that drosophila has all of the above.
I've had a nose around and can't find anything conclusive... I'll try again when I have a bit more time. Otherwise, anyone know for sure? Confuseddave 21:32, 23 January 2006 (UTC)
- Drosophila has one gene (hedgehog), mammals have three (sonic, desert, indian), zebrafish has five (sonic, desert, indian plus tiggywinkle and echidna). I'll try and make it clearer in the text. Rockpocket 22:55, 23 January 2006 (UTC)
[edit] Confusion in pathway details
This section of the article describes the Drosophila pathway, rather than the mammalian one. I will try to replace it with appropriate description. Please feel free to extend it. --Peter Znamenskiy | Talk 20:16, 20 May 2006 (GMT)
Hedgehog inducers bind to proteins of the Patched family, which are transmembrane proteins in the cell membranes of cells responsive to hedgehog. In the absence of hedghog Patched is bound to Smoothened, another membrane protein. This setup keeps the Cubitus interruptus (Ci) protein bound to microtubules in the cytoplasm of the cell, which leads to the cleaving of the protein. Part of the cleaved molecule then enters the nucleus and acts as a repressor to certain genes. When hedgehog binds to Patched, Smoothened allows Ci to dissociate from the microtubules, and hence remain as an intact protein. This protein also enters the nucleus, but in this state acts to activate the genes it once repressed.
[edit] Pathway diagram
I am working on a diagram illustrating the pathway. I'm including production of SHH (cleavage and attachment of cholesterol), its export with assistance of DISP and the PTCH -| SMO ->->-> GLI -> transcription cascade. Is there anything else you would like to see illustrated? --Peter Znamenskiy 19:23, 16 June 2006 (UTC)
[edit] Reorganisation
Okay, this is what I will try to do with this page and Hedgehog (cell signaling). Sonic hedgehog should only describe SHH itself as a protein. General pathway information goes on Hedgehog (cell signaling). I think it'd be a good approach to do the same for all cell signaling articles. Peter Z.Talk 22:16, 20 June 2006 (UTC)
- I've started the reorganisation. I'm sorry I leave this in a bit of a mess but I have to sleep now :) I'll continue with it tomorrow. Peter Z.Talk 23:31, 21 June 2006 (UTC)
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- Uh-huh - the mind has to be sharp otherwise it ain't that productive. -- Boris 01:38, 22 June 2006 (UTC)
- Good call!!! How about you say this loud and clear on our project's talk pages so everyone can hear you and i will back you up. -- Boris 01:38, 22 June 2006 (UTC)
[edit] References section
Something's wrong with the references. It starts 1, 2, 3, then starts over with 1 again. --Brandon Dilbeck 17:22, 23 September 2006 (UTC)
- People are using two different types of references in the page. The first three use the <ref> tag, the rest seem to use the {{cite}} template. 19:07, 31 October 2006 (UTC)
[edit] SHH to be renamed?
See e.g. http://www.geneticsandhealth.com/2006/11/12/hugo-changing-offensive-gene-names/ -- Mozjag 06:47, 13 November 2006 (UTC)
[edit] THe name
Did anyone know that this was actually named after Sonic the Hedgehog? -PrehistoricManiac08 (talk) 22:39, 11 May 2008 (UTC)
