Somatostatin receptor 3

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 182453 MGI: 98329 HomoloGene: 20285

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • receptor activity • somatostatin receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • cell-cell signaling • negative regulation of cell proliferation • induction of apoptosis by hormones

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001051 (mRNA)
NP_001042 (protein)

NM_009218 (mRNA)
NP_033244 (protein)

Location

Chr 22: 35.93 - 35.94 Mb

Chr 15: 78.36 - 78.37 Mb

Pubmed search

[1]

[2]

Somatostatin receptor 3, also known as SSTR3, is a human gene.^[1]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Somatostatin receptor

[edit] References

^ ^a ^b Entrez Gene: SSTR3 somatostatin receptor 3.

[edit] Further reading

Yamada Y, Reisine T, Law SF, et al. (1993). "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.". Mol. Endocrinol. 6 (12): 2136–42. PMID 1337145.
Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMID 1346068.
Corness JD, Demchyshyn LL, Seeman P, et al. (1993). "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.". FEBS Lett. 321 (2-3): 279–84. PMID 8097479.
Law SF, Zaina S, Sweet R, et al. (1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.". Mol. Pharmacol. 45 (4): 587–90. PMID 8183236.
Kaupmann K, Bruns C, Hoyer D, et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.". FEBS Lett. 331 (1-2): 53–9. PMID 8405411.
Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
Sharma K, Patel YC, Srikant CB (1997). "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.". Mol. Endocrinol. 10 (12): 1688–96. PMID 8961277.
Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines.". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. PMID 9177396.
de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997). "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization.". J. Biol. Chem. 272 (38): 23769–74. PMID 9295322.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.
Talme T, Ivanoff J, Hägglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.". Clin. Exp. Immunol. 125 (1): 71–9. PMID 11472428.
Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.
Ferone D, Pivonello R, Van Hagen PM, et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes.". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335.
Pasquali D, Notaro A, Bonavolonta' G, et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease.". J. Clin. Endocrinol. Metab. 87 (11): 5125–9. PMID 12414882.
Dizeyi N, Konrad L, Bjartell A, et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines.". Urol. Oncol. 7 (3): 91–8. PMID 12474541.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

[edit] External links

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened