Soluble epoxide hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a soluble epoxide hydrolase (EC 3.3.2.10) is an enzyme that catalyzes the chemical reaction

an epoxide + H₂O a glycol

Thus, the two substrates of this enzyme are epoxide and H₂O, whereas its product is glycol.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is epoxide hydrolase. Other names in common use include epoxide hydrase (ambiguous), epoxide hydratase (ambiguous), arene-oxide hydratase (ambiguous), aryl epoxide hydrase (ambiguous), trans-stilbene oxide hydrolase, sEH, and cytosolic epoxide hydrolase. This enzyme participates in arachidonic acid metabolism and tetrachloroethene degradation.

[edit] References

• IUBMB entry for 3.3.2.10
• BRENDA references for 3.3.2.10 (Recommended.)
• PubMed references for 3.3.2.10
• PubMed Central references for 3.3.2.10
• Google Scholar references for 3.3.2.10
• Newman JW, Morisseau C, Harris TR, Hammock BD (2003). "The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity". Proc. Natl. Acad. Sci. U. S. A. 100: 1558–63. PMID 12574510. 
• Oesch F, Arand M (2003). "The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase". Proc. Natl. Acad. Sci. U. S. A. 100: 1552–7. PMID 12574508. 
• Oesch F (1973). "Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds". Xenobiotica. 3: 305–40. PMID 4584115. 
• Morisseau C, Hammock BD (2005). "Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles". Annu. Rev. Pharmacol. Toxicol. 45: 311–33. PMID 15822179. 
• Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL (2000). "Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids". Circ. Res. 87: 992–8. PMID 11090543. 
• Lacourciere GM and Armstrong RN (1993). "The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate". J. Am. Chem. Soc. 115: 10466–10456. 
• Fretland AJ, Omiecinski CJ (2000). "Epoxide hydrolases: biochemistry and molecular biology". Chem. Biol. Interact. 129: 41–59. PMID 11154734. 
• Zeldin DC, Wei S, Falck JR, Hammock BD, Snapper JR, Capdevila JH (1995). "Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis". Arch. Biochem. Biophys. 316: 443–51. PMID 7840649. 
• Haeggstrom J, Meijer J, Radmark O (1986). "Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase". J. Biol. Chem. 261: 6332–7. PMID 3009453. 
• Newman JW, Morisseau C, Hammock BD (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid. Res. 44: 1–51. PMID 15748653. 

[edit] External links

• IUBMB entry for 3.3.2.10

• KEGG entry for 3.3.2.10

• BRENDA entry for 3.3.2.10

• NiceZyme view of 3.3.2.10

• EC2PDB: PDB structures for 3.3.2.10

• PRIAM entry for 3.3.2.10

• PUMA2 entry for 3.3.2.10

• IntEnz: Integrated Enzyme entry for 3.3.2.10

• MetaCyc entry for 3.3.2.10

• Atomic-resolution structures of enzymes belonging to this class