Sodium/proton antiporter 1
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| Na+/H+ antiporter 1 | ||
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| Identifiers | ||
| Symbol | Na_H_antiport_1 | |
| Pfam | PF06965 | |
| InterPro | IPR004670 | |
| TCDB | 2.A.36 | |
| OPM family | 66 | |
| OPM protein | 1zcd | |
| Available PDB structures:
1zcdA:4-380 |
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Na+/H+ antiporter 1 family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH [1].
In paricular, the Escherichia coli NhaA Na+:H+ Antiporter (NhaA) protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent.
[edit] References
- [1]. Expression of a sodium proton antiporter (NhaA) in Escherichia coli is induced by Na+ and Li+ ions. Karpel R, Alon T, Glaser G, Schuldiner S, Padan E; J Biol Chem 1991;266:21753-21759. PubMed
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This article includes text from the public domain Pfam and InterPro IPR004670
