SOD2

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Superoxide dismutase 2, mitochondrial
PDB rendering based on 1ap5.
Available structures: 1ap5, 1ap6, 1em1, 1ja8, 1luv, 1luw, 1msd, 1n0j, 1n0n, 1pl4, 1pm9, 1qnm, 1szx, 1var, 1xdc, 1xil, 1zsp, 1zte, 1zuq, 2adp, 2adq, 2gds, 2p4k
Identifiers
Symbol(s)	SOD2; IPO-B; MNSOD; Mn-SOD
External IDs	OMIM: 147460 MGI: 98352 HomoloGene: 530
Gene ontology Molecular Function: • superoxide dismutase activity • manganese superoxide dismutase activity • oxidoreductase activity • manganese ion binding • metal ion binding Cellular Component: • mitochondrion • mitochondrial inner membrane Biological Process: • response to superoxide • age-dependent response to reactive oxygen species • regulation of transcription from RNA polymerase II promoter • superoxide metabolic process • response to oxidative stress
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	6648	20656
Ensembl	ENSG00000112096	ENSMUSG00000006818
Uniprot	P04179	Q3TJA2
Refseq	NM_000636 (mRNA) NP_000627 (protein)	NM_013671 (mRNA) NP_038699 (protein)
Location	Chr 6: 160.02 - 160.03 Mb	Chr 17: 12.85 - 12.86 Mb
Pubmed search	[1]	[2]

Superoxide dismutase 2, mitochondrial, also known as SOD2, is a human gene.

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of the mitochondrial electron transport chain and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1] Mice lacking Sod2 die shortly after birth, indicating that the unchecked levels of superoxide are incompatible with mammalian life. However, mice 50% deficient in Sod2 have a normal lifespan and minimal phenotypic defects.

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