SOCS7

From Wikipedia, the free encyclopedia

Suppressor of cytokine signaling 7

Identifiers

External IDs

OMIM: 608788 MGI: 2651588 HomoloGene: 16331

Gene ontology
Molecular Function:	• protein binding • SH3 domain binding
Cellular Component:	• cellular_component
Biological Process:	• regulation of cell growth • intracellular signaling cascade • biological_process • insulin receptor signaling pathway • negative regulation of signal transduction • protein ubiquitination • fat cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_936572 (mRNA)
XP_941665 (protein)

XM_993570 (mRNA)
XP_998664 (protein)

Location

Chr 17: 33.76 - 33.81 Mb

Chr 11: 97.18 - 97.21 Mb

Pubmed search

[1]

[2]

Suppressor of cytokine signaling 7, also known as SOCS7, is a human gene.^[1]

[edit] References

^ Entrez Gene: SOCS7 suppressor of cytokine signaling 7.

[edit] Further reading

Cooney RN (2002). "Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway.". Shock 17 (2): 83–90. PMID 11837794.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Wormald S, Hilton DJ (2004). "Inhibitors of cytokine signal transduction.". J. Biol. Chem. 279 (2): 821–4. doi:10.1074/jbc.R300030200. PMID 14607831.
Fujimoto M, Naka T (2004). "Regulation of cytokine signaling by SOCS family molecules.". Trends Immunol. 24 (12): 659–66. PMID 14644140.
Matuoka K, Miki H, Takahashi K, Takenawa T (1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.". Biochem. Biophys. Res. Commun. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. PMID 9419338.
Dogusan Z, Hooghe-Peters EL, Berus D, et al. (2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines.". J. Neuroimmunol. 109 (1): 34–9. PMID 10969179.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567–78. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Martens N, Wery M, Wang P, et al. (2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.". Exp. Cell Res. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Martens N, Uzan G, Wery M, et al. (2005). "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.". J. Biol. Chem. 280 (14): 13817–23. doi:10.1074/jbc.M411596200. PMID 15677474.
Banks AS, Li J, McKeag L, et al. (2005). "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.". J. Clin. Invest. 115 (9): 2462–71. doi:10.1172/JCI23853. PMID 16127460.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMID 16625196.
Kremer BE, Adang LA, Macara IG (2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.". Cell 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMID 17803907.