SOCS6

From Wikipedia, the free encyclopedia

Suppressor of cytokine signaling 6

Identifiers

SOCS6; CIS4; HSPC060; SOCS4; SSI4; STAI4; STATI4

External IDs

OMIM: 605118 MGI: 1924885 HomoloGene: 3120

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytoplasm
Biological Process:	• regulation of cell growth • defense response • intracellular signaling cascade • JAK-STAT cascade • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004232 (mRNA)
NP_004223 (protein)

NM_018821 (mRNA)
NP_061291 (protein)

Location

Chr 18: 66.11 - 66.15 Mb

Chr 18: 89 - 89.03 Mb

Pubmed search

[1]

[2]

Suppressor of cytokine signaling 6, also known as SOCS6, is a human gene.^[1]

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.^[1]

[edit] References

^ ^a ^b Entrez Gene: SOCS6 suppressor of cytokine signaling 6.

[edit] Further reading

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235-41. PMID 12076535.
Masuhara M, Sakamoto H, Matsumoto A, et al. (1997). "Cloning and characterization of novel CIS family genes.". Biochem. Biophys. Res. Commun. 239 (2): 439-46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Mooney RA, Senn J, Cameron S, et al. (2001). "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.". J. Biol. Chem. 276 (28): 25889-93. doi:10.1074/jbc.M010579200. PMID 11342531.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567-78. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.". J. Biol. Chem. 279 (13): 12249-59. doi:10.1074/jbc.M313381200. PMID 14707129.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Bayle J, Lopez S, Iwaï K, et al. (2006). "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.". FEBS Lett. 580 (11): 2609-14. doi:10.1016/j.febslet.2006.03.093. PMID 16643902.
Hwang MN, Ha TH, Park J, et al. (2007). "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.". Biochem. Biophys. Res. Commun. 354 (1): 184-9. doi:10.1016/j.bbrc.2006.12.175. PMID 17210122.
Hwang MN, Min CH, Kim HS, et al. (2007). "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels.". Biochem. Biophys. Res. Commun. 360 (2): 333-8. doi:10.1016/j.bbrc.2007.06.062. PMID 17603019.