SOCS3

From Wikipedia, the free encyclopedia

Suppressor of cytokine signaling 3

PDB rendering based on 2bbu.

Available structures: 2bbu

Identifiers

Symbol(s)

SOCS3; ATOD4; CIS3; Cish3; MGC71791; SOCS-3; SSI-3; SSI3

External IDs

OMIM: 604176 MGI: 1201791 HomoloGene: 2941

Gene ontology
Molecular Function:	• protein kinase inhibitor activity • protein binding
Biological Process:	• regulation of cell growth • regulation of protein amino acid phosphorylation • anti-apoptosis • intracellular signaling cascade • JAK-STAT cascade • negative regulation of insulin receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003955 (mRNA)
NP_003946 (protein)

NM_007707 (mRNA)
NP_031733 (protein)

Location

Chr 17: 73.86 - 73.87 Mb

Chr 11: 117.78 - 117.79 Mb

Pubmed search

[1]

[2]

Suppressor of cytokine signaling 3, also known as SOCS3, is a human gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.^[1]

[edit] See also

[edit] References

^ Entrez Gene: SOCS3 suppressor of cytokine signaling 3.

[edit] Further reading

Yasukawa H, Sasaki A, Yoshimura A (2000). "Negative regulation of cytokine signaling pathways.". Annu. Rev. Immunol. 18: 143–64. doi:10.1146/annurev.immunol.18.1.143. PMID 10837055.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Minamoto S, Ikegame K, Ueno K, et al. (1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.". Biochem. Biophys. Res. Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
Masuhara M, Sakamoto H, Matsumoto A, et al. (1997). "Cloning and characterization of novel CIS family genes.". Biochem. Biophys. Res. Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
Zhang JG, Farley A, Nicholson SE, et al. (1999). "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2071–6. PMID 10051596.
Sasaki A, Yasukawa H, Suzuki A, et al. (1999). "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.". Genes Cells 4 (6): 339–51. PMID 10421843.
Marine JC, McKay C, Wang D, et al. (1999). "SOCS3 is essential in the regulation of fetal liver erythropoiesis.". Cell 98 (5): 617–27. PMID 10490101.
Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.". J. Biol. Chem. 274 (50): 35553–61. PMID 10585430.
Sasaki A, Yasukawa H, Shouda T, et al. (2000). "CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.". J. Biol. Chem. 275 (38): 29338–47. doi:10.1074/jbc.M003456200. PMID 10882725.
Anhuf D, Weissenbach M, Schmitz J, et al. (2000). "Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.". J. Immunol. 165 (5): 2535–43. PMID 10946280.
Bjorbak C, Lavery HJ, Bates SH, et al. (2001). "SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.". J. Biol. Chem. 275 (51): 40649–57. doi:10.1074/jbc.M007577200. PMID 11018044.
Shen X, Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.". FEBS Lett. 480 (2-3): 132–6. PMID 11034314.
Dey BR, Furlanetto RW, Nissley P (2001). "Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.". Biochem. Biophys. Res. Commun. 278 (1): 38–43. doi:10.1006/bbrc.2000.3762. PMID 11071852.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Cookson WO, Ubhi B, Lawrence R, et al. (2001). "Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.". Nat. Genet. 27 (4): 372–3. doi:10.1038/86867. PMID 11279517.
Cacalano NA, Sanden D, Johnston JA (2001). "Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras.". Nat. Cell Biol. 3 (5): 460–5. doi:10.1038/35074525. PMID 11331873.
Roberts AW, Robb L, Rakar S, et al. (2001). "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9324–9. doi:10.1073/pnas.161271798. PMID 11481489.
Dif F, Saunier E, Demeneix B, et al. (2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor.". Endocrinology 142 (12): 5286–93. PMID 11713228.
Bode JG, Ludwig S, Freitas CA, et al. (2002). "The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription.". Biol. Chem. 382 (10): 1447–53. PMID 11727828.