SOCS2

From Wikipedia, the free encyclopedia

Suppressor of cytokine signaling 2

PDB rendering based on 2c9w.

Available structures: 2c9w

Identifiers

Symbol(s)

SOCS2; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2

External IDs

OMIM: 605117 MGI: 1201787 HomoloGene: 2880

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • growth hormone receptor binding • prolactin receptor binding • insulin-like growth factor receptor binding • protein binding • JAK pathway signal transduction adaptor activity
Cellular Component:	• cytoplasm
Biological Process:	• regulation of cell growth • anti-apoptosis • intracellular signaling cascade • JAK-STAT cascade • negative regulation of signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003877 (mRNA)
NP_003868 (protein)

NM_007706 (mRNA)
NP_031732 (protein)

Location

Chr 12: 92.49 - 92.49 Mb

Chr 10: 94.82 - 94.85 Mb

Pubmed search

[1]

[2]

Suppressor of cytokine signaling 2, also known as SOCS2, is a human gene.^[1]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.^[1]

[edit] References

^ ^a ^b Entrez Gene: SOCS2 suppressor of cytokine signaling 2.

[edit] Further reading

Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I.". Acta Biochim. Pol. 46 (1): 51–60. PMID 10453981.
Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. PMID 11835308.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Pezet A, Buteau H, Kelly PA, Edery M (1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor.". Mol. Cell. Endocrinol. 129 (2): 199–208. PMID 9202403.
Minamoto S, Ikegame K, Ueno K, et al. (1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.". Biochem. Biophys. Res. Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
Masuhara M, Sakamoto H, Matsumoto A, et al. (1997). "Cloning and characterization of novel CIS family genes.". Biochem. Biophys. Res. Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
Dey BR, Spence SL, Nissley P, Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.". J. Biol. Chem. 273 (37): 24095–101. PMID 9727029.
Pezet A, Favre H, Kelly PA, Edery M (1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling.". J. Biol. Chem. 274 (35): 24497–502. PMID 10455112.
Yandava CN, Pillari A, Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.". Genomics 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.
Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.". J. Biol. Chem. 274 (50): 35553–61. PMID 10585430.
Metcalf D, Greenhalgh CJ, Viney E, et al. (2000). "Gigantism in mice lacking suppressor of cytokine signalling-2.". Nature 405 (6790): 1069–73. doi:10.1038/35016611. PMID 10890450.
Shen X, Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.". FEBS Lett. 480 (2-3): 132–6. PMID 11034314.
Eyckerman S, Verhee A, der Heyden JV, et al. (2002). "Design and application of a cytokine-receptor-based interaction trap.". Nat. Cell Biol. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. PMID 11781573.
Schultheis B, Carapeti-Marootian M, Hochhaus A, et al. (2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism.". Blood 99 (5): 1766–75. PMID 11861294.
Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD (2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor.". J. Clin. Endocrinol. Metab. 87 (3): 1094–7. PMID 11889171.
Biener E, Maurice S, Sandowski Y, et al. (2003). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization.". Protein Expr. Purif. 25 (2): 305–12. PMID 12135564.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.