SNX5

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex ^[2], which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to fanconi anemia complementation group A protein. This gene results in two transcript variants encoding the same protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX5 sorting nexin 5.
^ Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ. (2007) A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. Journal of Cell Science 120, 45-54 Entrez PubMed 17148574

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Otsuki T, Kajigaya S, Ozawa K, Liu JM (2000). "SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein.". Biochem. Biophys. Res. Commun. 265 (3): 630–5. doi:10.1006/bbrc.1999.1731. PMID 10600472.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7–16. PMID 11485546.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Towler MC, Gleeson PA, Hoshino S, et al. (2005). "Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.". Mol. Biol. Cell 15 (7): 3181–95. doi:10.1091/mbc.E04-03-0249. PMID 15133132.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Merino-Trigo A, Kerr MC, Houghton F, et al. (2005). "Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation.". J. Cell. Sci. 117 (Pt 26): 6413–24. doi:10.1242/jcs.01561. PMID 15561769.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Wassmer T, Attar N, Bujny MV, et al. (2007). "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.". J. Cell. Sci. 120 (Pt 1): 45–54. doi:10.1242/jcs.03302. PMID 17148574.