SNX27

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Sorting nexin family member 27
Identifiers
Symbol(s) SNX27; KIAA0488; MGC126871; MGC126873; MGC20471; MY014
External IDs MGI: 1923992 HomoloGene: 12797
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 81609 76742
Ensembl ENSG00000143376 ENSMUSG00000028136
Uniprot Q96L92 n/a
Refseq NM_030918 (mRNA)
NP_112180 (protein)		 XM_131051 (mRNA)
XP_131051 (protein)
Location Chr 1: 149.85 - 149.94 Mb Chr 3: 94.58 - 94.67 Mb
Pubmed search [1] [2]

Sorting nexin family member 27, also known as SNX27, is a human gene.[1]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.[1]

[edit] References

  1. ^ a b Entrez Gene: SNX27 sorting nexin family member 27.

[edit] Further reading

  • Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins.". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.". DNA Res. 4 (5): 345–9. PMID 9455484. 
  • Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7–16. PMID 11485546. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Williams R, Schlüter T, Roberts MS, et al. (2005). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.". Mol. Biol. Cell 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMID 15121882. 
  • Joubert L, Hanson B, Barthet G, et al. (2005). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.". J. Cell. Sci. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Rincón E, Santos T, Avila-Flores A, et al. (2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling.". Mol. Cell Proteomics 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151. 
  • MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes.". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583. 
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