SNX26

From Wikipedia, the free encyclopedia

Sorting nexin 26

Identifiers

SNX26; FLJ39019; TCGAP

External IDs

Gene ontology
Molecular Function:	• GTPase activator activity • protein binding • Rac GTPase activator activity
Cellular Component:	• intracellular • cytoplasm • plasma membrane
Biological Process:	• signal transduction • protein transport

Orthologs

Human

Mouse

Refseq

NM_052948 (mRNA)
NP_443180 (protein)

NM_178252 (mRNA)
NP_839983 (protein)

Location

Chr 19: 40.96 - 40.97 Mb

Chr 7: 30.23 - 30.24 Mb

Pubmed search

[1]

[2]

Sorting nexin 26, also known as SNX26, is a human gene.^[1]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX26 sorting nexin 26.

[edit] Further reading

Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling.". Biochem. J. 360 (Pt 3): 513-30. PMID 11736640.
Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships.". FEBS Lett. 528 (1-3): 27-34. PMID 12297274.
Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins.". Nat. Rev. Mol. Cell Biol. 3 (12): 919-31. doi:10.1038/nrm974. PMID 12461558.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.". Science 293 (5527): 104-11. doi:10.1126/science.1060310. PMID 11441184.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7-16. PMID 11485546.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chiang SH, Hwang J, Legendre M, et al. (2003). "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport.". EMBO J. 22 (11): 2679-91. doi:10.1093/emboj/cdg262. PMID 12773384.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Liu H, Nakazawa T, Tezuka T, Yamamoto T (2006). "Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.". J. Biol. Chem. 281 (33): 23611-9. doi:10.1074/jbc.M511205200. PMID 16777849.