SNX17

From Wikipedia, the free encyclopedia

Sorting nexin 17

Identifiers

SNX17; KIAA0064

External IDs

OMIM: 605963 MGI: 2387801 HomoloGene: 8838

Gene ontology
Molecular Function:	• receptor binding • protein C-terminus binding • phosphoinositide binding
Cellular Component:	• cytoplasm • early endosome • Golgi apparatus • membrane
Biological Process:	• intracellular protein transport • receptor-mediated endocytosis • signal transduction • endosome transport • regulation of endocytosis • low-density lipoprotein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014748 (mRNA)
NP_055563 (protein)

NM_153680 (mRNA)
NP_710147 (protein)

Location

Chr 2: 27.45 - 27.45 Mb

Chr 5: 31.47 - 31.48 Mb

Pubmed search

[1]

[2]

Sorting nexin 17, also known as SNX17, is a human gene.^[1]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX17 sorting nexin 17.

[edit] Further reading

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223-9. PMID 7584044.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239-46. doi:10.1006/excr.2000.4948. PMID 10942595.
Florian V, Schlüter T, Bohnensack R (2001). "A new member of the sorting nexin family interacts with the C-terminus of P-selectin.". Biochem. Biophys. Res. Commun. 281 (4): 1045-50. doi:10.1006/bbrc.2001.4467. PMID 11237770.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7-16. PMID 11485546.
Stockinger W, Sailler B, Strasser V, et al. (2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.". EMBO J. 21 (16): 4259-67. PMID 12169628.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Burden JJ, Sun XM, García AB, Soutar AK (2004). "Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17.". J. Biol. Chem. 279 (16): 16237-45. doi:10.1074/jbc.M313689200. PMID 14739284.
Williams R, Schlüter T, Roberts MS, et al. (2005). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.". Mol. Biol. Cell 15 (7): 3095-105. doi:10.1091/mbc.E04-02-0143. PMID 15121882.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Knauth P, Schlüter T, Czubayko M, et al. (2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.". J. Mol. Biol. 347 (4): 813-25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
van Kerkhof P, Lee J, McCormick L, et al. (2006). "Sorting nexin 17 facilitates LRP recycling in the early endosome.". EMBO J. 24 (16): 2851-61. doi:10.1038/sj.emboj.7600756. PMID 16052210.
Czubayko M, Knauth P, Schlüter T, et al. (2006). "Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1.". Biochem. Biophys. Res. Commun. 345 (3): 1264-72. doi:10.1016/j.bbrc.2006.04.129. PMID 16712798.