SNX15

From Wikipedia, the free encyclopedia

Sorting nexin 15

Identifiers

SNX15; HSAF001435

External IDs

OMIM: 605964 MGI: 1916274 HomoloGene: 12294

Gene ontology
Molecular Function:	• protein binding • protein transporter activity • phosphoinositide binding
Cellular Component:	• cytosol • membrane
Biological Process:	• intracellular protein transport • cell communication

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_013306 (mRNA)
NP_037438 (protein)

NM_026912 (mRNA)
NP_081188 (protein)

Location

n/a

Chr 19: 6.12 - 6.13 Mb

Pubmed search

[1]

[2]

Sorting nexin 15, also known as SNX15, is a human gene.^[1]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX15 sorting nexin 15.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Guru SC, Agarwal SK, Manickam P, et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.". Genome Res. 7 (7): 725-35. PMID 9253601.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Phillips SA, Barr VA, Haft DH, et al. (2001). "Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking.". J. Biol. Chem. 276 (7): 5074-84. doi:10.1074/jbc.M004671200. PMID 11085978.
Barr VA, Phillips SA, Taylor SI, Haft CR (2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking.". Traffic 1 (11): 904-16. PMID 11208079.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.