SNX13

From Wikipedia, the free encyclopedia

Sorting nexin 13

Identifiers

SNX13; KIAA0713; RGS-PX1

External IDs

OMIM: 606589 MGI: 2661416 HomoloGene: 41011

Gene ontology
Molecular Function:	• signal transducer activity • protein binding • phosphoinositide binding
Biological Process:	• cell communication • intracellular signaling cascade • negative regulation of signal transduction • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015132 (mRNA)
NP_055947 (protein)

NM_001014973 (mRNA)
NP_001014973 (protein)

Location

Chr 7: 17.8 - 17.95 Mb

Chr 12: 35.63 - 35.73 Mb

Pubmed search

[1]

[2]

Sorting nexin 13, also known as SNX13, is a human gene.^[1]

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNX13 sorting nexin 13.

[edit] Further reading

Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins.". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1.". Biochem. J. 358 (Pt 1): 7–16. PMID 11485546.
Zheng B, Ma YC, Ostrom RS, et al. (2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.". Science 294 (5548): 1939–42. doi:10.1126/science.1064757. PMID 11729322.
Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region.". Cytogenet. Genome Res. 97 (3-4): 167–70. PMID 12438708.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.