SNRPG

From Wikipedia, the free encyclopedia

Small nuclear ribonucleoprotein polypeptide G

Identifiers

SNRPG; MGC117317; SMG

External IDs

OMIM: 603542 MGI: 1915261 HomoloGene: 37730

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus • spliceosome • small nuclear ribonucleoprotein complex
Biological Process:	• spliceosome assembly • mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003096 (mRNA)
NP_003087 (protein)

NM_026506 (mRNA)
NP_080782 (protein)

Location

Chr 2: 70.36 - 70.37 Mb

n/a

Pubmed search

[1]

[2]

Small nuclear ribonucleoprotein polypeptide G, also known as SNRPG, is a human gene.^[1]

[edit] References

^ Entrez Gene: SNRPG small nuclear ribonucleoprotein polypeptide G.

[edit] Further reading

Heinrichs V, Hackl W, Lührmann R (1992). "Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro.". J. Mol. Biol. 227 (1): 15–28. PMID 1387914.
Hermann H, Fabrizio P, Raker VA, et al. (1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions.". EMBO J. 14 (9): 2076–88. PMID 7744013.
Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core.". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins.". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.". Hum. Mol. Genet. 8 (13): 2351–7. PMID 10556282.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181–94. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177–86. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.". EMBO J. 20 (1-2): 187–96. doi:10.1093/emboj/20.1.187. PMID 11226169.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Conte N, Charafe-Jauffret E, Delaval B, et al. (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators.". Oncogene 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Conte N, Delaval B, Ginestier C, et al. (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer.". Oncogene 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.". RNA 10 (6): 929–41. PMID 15146077.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure.". Structure 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.