SNRPA1

From Wikipedia, the free encyclopedia

Small nuclear ribonucleoprotein polypeptide A'

PDB rendering based on 1a9n.

Available structures: 1a9n

Identifiers

Symbol(s)

SNRPA1;

External IDs

OMIM: 603521 MGI: 1916231 HomoloGene: 2325

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus • spliceosome • snRNP U2 • ribonucleoprotein complex
Biological Process:	• nuclear mRNA splicing, via spliceosome • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003090 (mRNA)
NP_003081 (protein)

XM_977363 (mRNA)
XP_982457 (protein)

Location

Chr 15: 99.64 - 99.65 Mb

Chr 7: 65.94 - 65.95 Mb

Pubmed search

[1]

[2]

Small nuclear ribonucleoprotein polypeptide A', also known as SNRPA1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'.

[edit] Further reading

Ohno M, Kataoka N, Shimura Y (1991). "A nuclear cap binding protein from HeLa cells.". Nucleic Acids Res. 18 (23): 6989-95. PMID 2148205.
Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein.". Nucleic Acids Res. 17 (5): 1893-906. PMID 2928112.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Kjems J, Sharp PA (1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly.". J. Virol. 67 (8): 4769-76. PMID 8331728.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (1998). "A coactivator of pre-mRNA splicing.". Genes Dev. 12 (7): 996-1009. PMID 9531537.
Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.". Nature 394 (6694): 645-50. doi:10.1038/29234. PMID 9716128.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46-50. doi:10.1038/1700. PMID 9731529.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125-30. PMID 10339552.
Lundin M, Mikkelsen B, Gudim M, Syed M. "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed." 2 (2): 204-211. PMID 10811961.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature 414 (6866): 929-33. doi:10.1038/414929a. PMID 11780068.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426-39. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.