Snake toxins

Snake toxin
Identifiers
Symbol	Toxin_1
Pfam	PF00087
InterPro	IPR003571
PROSITE	PDOC00245
SCOP	2ctx
OPM family	55
OPM protein	1txa
Available PDB structures: 1ntx :1-60 2era :22-83 3eraB:22-83 1qke :22-83 1qkdA:22-83 5ebx :22-83 1fra :22-83 3ebx :22-83 6ebxA:22-83 1nxb :22-83 1era :22-83 1nea :1-61 1iq9A:1-61 1lnkA:1-61 1v6pA:22-83 1coe :22-83 1cod :22-83 1g6mA:1-62 1y5tA:22-82 1y5sA:22-82 1vb0A:22-82 1onjA:22-82 1nor :1-61 1je9A:1-61 1txa :1-65 1txb :1-65 2ctx :1-64 1yi5F:1-64 1lxgA:1-64 1lxhA:1-64 1ctx :1-64 2abxA:22-87 1idiA:22-88 1jbdA:22-88 1ljzA:22-88 1haaA:22-88 1l4wA:22-88 1idlA:22-88 1lk1F:22-88 1bxpA:22-88 1ikcA:22-88 1hajA:22-88 1idhA:22-88 1kfhA:22-88 1abtA:22-88 1hoyA:22-88 1rgjA:22-88 1idgA:22-88 2btxA:22-88 1kc4A:22-88 1kl8A:22-88 1ik8A:22-88 1ntn :1-66 1w6bA:1-66 1lsi :22-85 1kbaB:22-87 2nbtA:22-87 1jgkA:25-87 1lq3A:1-65 1xw1A:1-65 1y5pA:1-65 1y5qA:1-65 1lmgA:1-65 1xw0A:1-65 1ln9A:1-65 1y6cA:22-86 1y68A:22-86 1xvzA:1-62 1ln7A:1-62 1ff4A:22-86 1ug4A:22-81 1cb9A:1-60 1ccqA:1-60 1ffjA:1-60 1i02A:22-81 1xt3B:22-81 1h0jA:22-81 2crt :22-81 2crs :22-81 2cdx :22-81 1rl5A:1-60 1chvS:1-60 1kbt :22-81 1kbs :22-81 1cre :22-81 1crf :22-81 1cdtA:1-60 2ccx :1-60 1cxo :1-60 1tgxA:1-60 1cxn :1-60 1kxiB:22-83 1cvo :22-83 1tfs :1-60 1drs :1-59 1vylA:1-57 1ijcA:1-63 1f94A:1-63

Snake toxin is a family of venomous protein neurotoxins and cytotoxins. Most of these toxins act by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and prevent the binding of acetylcholine, thereby blocking the excitation of muscles. Their structure is small, disulfide-rich, and nearly all beta-sheet.

[edit] Subfamilies

[1]. Classification of elapid snake neurotoxins and cytotoxins according to chain length: evolutionary implications. Dufton MJ; J Mol Evol 1984;20:128-134. PubMed
[2]. Finding flexible patterns in unaligned protein sequences. Jonassen I, Collins JF, Higgins DG; Protein Sci 1995;4:1587-1595. PubMed