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| Snake H/ACA box small nucleolar RNA |
 |
| Type: |
Gene; snRNA; guide; HACA-box; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
140.3 nucleotides |
| Avg identity: |
90% |
|
Snake H/ACA box small nucleolar RNA refers to a number of very closely related non-coding RNA (ncRNA) genes identified in snakes which have been predicted to be small nucleolar RNAs (snoRNAs) . This type of ncRNA is involved in the biogeneisis of other small nuclear RNAs and are often referred to as 'guide' RNAs. They are usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.
These snoRNA genes were initially identified in the introns of the cardiotoxin 4 and cobrotoxin genes of the Taiwan cobra (Bungarus multicinctus) and the Taiwan banded krait (Bungarus multicinctus) during sequencing of these genes [1][2] These snoRNAs are predicted to act as H/ACA box type methylation guides as they have the predicted hairpin-hinge-hairpin-tail structure[3] and extended regions of complementarity to 5S ribosomal RNA (rRNA).
[edit] References
- ^ Chang LS, Lin SK, Wu PF (1998). "Differentially expressed snoRNAs in Bungarus multicinctus (Taiwan banded krait)". Biochem. Biophys. Res. Commun. 245 (2): 397–402. doi:10.1006/bbrc.1998.8433. PMID 9571162.
- ^ Chang L, Hong E (1997). "Novel SnoRNAs from Naja naja atra (Taiwan cobra) and Bungarus multicinctus (Taiwan banded krait), form extended sequence complementarity to 5S rRNA". Biochem. Biophys. Res. Commun. 236 (3): 782–4. PMID 9245733.
- ^ Ganot P, Caizergues-Ferrer M, Kiss T (1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes Dev. 11 (7): 941–56. PMID 9106664.
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