SNAP29

From Wikipedia, the free encyclopedia

Synaptosomal-associated protein, 29kDa

Identifiers

SNAP29; CEDNIK; FLJ21051; SNAP-29

External IDs

OMIM: 604202 MGI: 1914724 HomoloGene: 3512

Gene ontology
Molecular Function:	• SNAP receptor activity
Cellular Component:	• plasma membrane • synaptosome • synapse
Biological Process:	• exocytosis • vesicle targeting • membrane fusion • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004782 (mRNA)
NP_004773 (protein)

NM_023348 (mRNA)
NP_075837 (protein)

Location

Chr 22: 19.54 - 19.57 Mb

Chr 16: 17.32 - 17.34 Mb

Pubmed search

[1]

[2]

Synaptosomal-associated protein, 29kDa, also known as SNAP29, is a human gene.^[1]

This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNAP29 synaptosomal-associated protein, 29kDa.

[edit] Further reading

Steegmaier M, Yang B, Yoo JS, et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family.". J. Biol. Chem. 273 (51): 34171–9. PMID 9852078.
Wong SH, Xu Y, Zhang T, et al. (1999). "GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6.". Mol. Biol. Cell 10 (1): 119–34. PMID 9880331.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Scales SJ, Chen YA, Yoo BY, et al. (2000). "SNAREs contribute to the specificity of membrane fusion.". Neuron 26 (2): 457–64. PMID 10839363.
Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
Hohenstein AC, Roche PA (2001). "SNAP-29 is a promiscuous syntaxin-binding SNARE.". Biochem. Biophys. Res. Commun. 285 (2): 167–71. doi:10.1006/bbrc.2001.5141. PMID 11444821.
Su Q, Mochida S, Tian JH, et al. (2002). "SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission.". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 14038–43. doi:10.1073/pnas.251532398. PMID 11707603.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Martinez-Arca S, Rudge R, Vacca M, et al. (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs.". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMID 12853575.
Xu Y, Shi H, Wei S, et al. (2005). "Mutually exclusive interactions of EHD1 with GS32 and syndapin II.". Mol. Membr. Biol. 21 (4): 269–77. doi:10.1080/09687680410001716871. PMID 15371016.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Pan PY, Cai Q, Lin L, et al. (2005). "SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons.". J. Biol. Chem. 280 (27): 25769–79. doi:10.1074/jbc.M502356200. PMID 15890653.
Sprecher E, Ishida-Yamamoto A, Mizrahi-Koren M, et al. (2005). "A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma.". Am. J. Hum. Genet. 77 (2): 242–51. doi:10.1086/432556. PMID 15968592.
Carroll JS, Liu XS, Brodsky AS, et al. (2005). "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.". Cell 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.