SNAI1

From Wikipedia, the free encyclopedia

Snail homolog 1 (Drosophila)

Identifiers

SNAI1; SLUGH2; SNA; SNAH; dJ710H13.1

External IDs

OMIM: 604238 MGI: 98330 HomoloGene: 4363

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• cartilage condensation • multicellular organismal development • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005985 (mRNA)
NP_005976 (protein)

NM_011427 (mRNA)
NP_035557 (protein)

Location

Chr 20: 48.03 - 48.04 Mb

Chr 2: 167.23 - 167.23 Mb

Pubmed search

[1]

[2]

Snail homolog 1 (Drosophila), also known as SNAI1, is a human gene.^[1]

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.^[1]

[edit] References

^ ^a ^b Entrez Gene: SNAI1 snail homolog 1 (Drosophila).

[edit] Further reading

Twigg SR, Wilkie AO (1999). "Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis.". Hum. Genet. 105 (4): 320-6. PMID 10543399.
Paznekas WA, Okajima K, Schertzer M, et al. (2000). "Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P).". Genomics 62 (1): 42-9. doi:10.1006/geno.1999.6010. PMID 10585766.
Batlle E, Sancho E, Francí C, et al. (2000). "The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.". Nat. Cell Biol. 2 (2): 84-9. doi:10.1038/35000034. PMID 10655587.
Smith S, Metcalfe JA, Elgar G (2000). "Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q.". Gene 247 (1-2): 119-28. PMID 10773451.
Okubo T, Truong TK, Yu B, et al. (2001). "Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH).". Cancer Res. 61 (4): 1338-46. PMID 11245431.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Blanco MJ, Moreno-Bueno G, Sarrio D, et al. (2002). "Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.". Oncogene 21 (20): 3241-6. doi:10.1038/sj.onc.1205416. PMID 12082640.
Guaita S, Puig I, Franci C, et al. (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.". J. Biol. Chem. 277 (42): 39209-16. doi:10.1074/jbc.M206400200. PMID 12161443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yokoyama K, Kamata N, Fujimoto R, et al. (2003). "Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas.". Int. J. Oncol. 22 (4): 891-8. PMID 12632084.
Ikenouchi J, Matsuda M, Furuse M, Tsukita S (2004). "Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail.". J. Cell. Sci. 116 (Pt 10): 1959-67. doi:10.1242/jcs.00389. PMID 12668723.
Domínguez D, Montserrat-Sentís B, Virgós-Soler A, et al. (2003). "Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor.". Mol. Cell. Biol. 23 (14): 5078-89. PMID 12832491.
Imai T, Horiuchi A, Wang C, et al. (2003). "Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells.". Am. J. Pathol. 163 (4): 1437-47. PMID 14507651.
Miyoshi A, Kitajima Y, Sumi K, et al. (2004). "Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells.". Br. J. Cancer 90 (6): 1265-73. doi:10.1038/sj.bjc.6601685. PMID 15026811.
Ohkubo T, Ozawa M (2004). "The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation.". J. Cell. Sci. 117 (Pt 9): 1675-85. doi:10.1242/jcs.01004. PMID 15075229.
Barberà MJ, Puig I, Domínguez D, et al. (2004). "Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells.". Oncogene 23 (44): 7345-54. doi:10.1038/sj.onc.1207990. PMID 15286702.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Kajita M, McClinic KN, Wade PA (2004). "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.". Mol. Cell. Biol. 24 (17): 7559-66. doi:10.1128/MCB.24.17.7559-7566.2004. PMID 15314165.
Zhou BP, Deng J, Xia W, et al. (2004). "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.". Nat. Cell Biol. 6 (10): 931-40. doi:10.1038/ncb1173. PMID 15448698.
Saito T, Oda Y, Kawaguchi K, et al. (2004). "E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma.". Oncogene 23 (53): 8629-38. doi:10.1038/sj.onc.1207960. PMID 15467754.