SMYD3

From Wikipedia, the free encyclopedia

SET and MYND domain containing 3

Identifiers

SMYD3; FLJ21080; MGC104324; ZMYND1; ZNFN3A1; bA74P14.1

External IDs

OMIM: 608783 MGI: 1916976 HomoloGene: 41491

Gene ontology
Molecular Function:	• protein binding • methyltransferase activity • zinc ion binding • transferase activity • histone-lysine N-methyltransferase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022743 (mRNA)
NP_073580 (protein)

NM_027188 (mRNA)
NP_081464 (protein)

Location

Chr 1: 243.98 - 244.74 Mb

Chr 1: 180.79 - 181.35 Mb

Pubmed search

[1]

[2]

SET and MYND domain containing 3, also known as SMYD3, is a human gene.^[1]

SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SMYD3 SET and MYND domain containing 3.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hamamoto R, Furukawa Y, Morita M, et al. (2004). "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.". Nat. Cell Biol. 6 (8): 731–40. doi:10.1038/ncb1151. PMID 15235609.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhou Z, Ren X, Huang X, et al. (2006). "SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in human spermatogenesis.". Ann. Clin. Lab. Sci. 35 (3): 270–7. PMID 16081583.
Tsuge M, Hamamoto R, Silva FP, et al. (2005). "A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.". Nat. Genet. 37 (10): 1104–7. doi:10.1038/ng1638. PMID 16155568.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hamamoto R, Silva FP, Tsuge M, et al. (2006). "Enhanced SMYD3 expression is essential for the growth of breast cancer cells.". Cancer Sci. 97 (2): 113–8. doi:10.1111/j.1349-7006.2006.00146.x. PMID 16441421.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Wang XQ, Miao X, Cai Q, et al. (2007). "SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population.". Exp. Oncol. 29 (1): 71–3. PMID 17431393.