SMURF2

From Wikipedia, the free encyclopedia

SMAD specific E3 ubiquitin protein ligase 2

PDB rendering based on 1zvd.

Available structures: 1zvd, 2djy

Identifiers

Symbol(s)

SMURF2; DKFZp686F0270; MGC138150

External IDs

OMIM: 605532 MGI: 1913563 HomoloGene: 41490

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • ligase activity
Cellular Component:	• ubiquitin ligase complex • intracellular • nucleus
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle • negative regulation of transcription • regulation of transforming growth factor beta receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_022739 (mRNA)
NP_073576 (protein)

XM_001001801 (mRNA)
XP_001001801 (protein)

Location

Chr 17: 59.97 - 60.09 Mb

Chr 11: 106.64 - 106.74 Mb

Pubmed search

[1]

[2]

SMAD specific E3 ubiquitin protein ligase 2, also known as SMURF2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2.

[edit] Further reading

Lin X, Liang M, Feng XH (2001). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.". J. Biol. Chem. 275 (47): 36818-22. doi:10.1074/jbc.C000580200. PMID 11016919.
Zhang Y, Chang C, Gehling DJ, et al. (2001). "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 974-9. doi:10.1073/pnas.98.3.974. PMID 11158580.
Kavsak P, Rasmussen RK, Causing CG, et al. (2001). "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.". Mol. Cell 6 (6): 1365-75. PMID 11163210.
Bonni S, Wang HR, Causing CG, et al. (2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.". Nat. Cell Biol. 3 (6): 587-95. doi:10.1038/35078562. PMID 11389444.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Subramaniam V, Li H, Wong M, et al. (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.". Br. J. Cancer 89 (8): 1538-44. doi:10.1038/sj.bjc.6601301. PMID 14562029.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Asano Y, Ihn H, Yamane K, et al. (2004). "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.". J. Clin. Invest. 113 (2): 253-64. doi:10.1172/JCI200416269. PMID 14722617.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.". Oncogene 23 (10): 1801-8. doi:10.1038/sj.onc.1207319. PMID 14755250.
Jin YH, Jeon EJ, Li QL, et al. (2004). "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.". J. Biol. Chem. 279 (28): 29409-17. doi:10.1074/jbc.M313120200. PMID 15138260.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang H, Cohen SN (2005). "Smurf2 up-regulation activates telomere-dependent senescence.". Genes Dev. 18 (24): 3028-40. doi:10.1101/gad.1253004. PMID 15574587.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Ohashi N, Yamamoto T, Uchida C, et al. (2005). "Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta.". FEBS Lett. 579 (12): 2557-63. doi:10.1016/j.febslet.2005.03.069. PMID 15862290.
Ogunjimi AA, Briant DJ, Pece-Barbara N, et al. (2005). "Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.". Mol. Cell 19 (3): 297-308. doi:10.1016/j.molcel.2005.06.028. PMID 16061177.
Chong PA, Lin H, Wrana JL, Forman-Kay JD (2006). "An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.". J. Biol. Chem. 281 (25): 17069-75. doi:10.1074/jbc.M601493200. PMID 16641086.
Wiesner S, Ogunjimi AA, Wang HR, et al. (2007). "Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.". Cell 130 (4): 651-62. doi:10.1016/j.cell.2007.06.050. PMID 17719543.