SMURF1

From Wikipedia, the free encyclopedia

SMAD specific E3 ubiquitin protein ligase 1

Identifiers

SMURF1; KIAA1625

External IDs

OMIM: 605568 MGI: 1923038 HomoloGene: 10712

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • ligase activity
Cellular Component:	• intracellular
Biological Process:	• ubiquitin cycle • ectoderm development • cell differentiation • negative regulation of BMP signaling pathway • protein ubiquitination during ubiquitin-dependent protein catabolic process

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_020429 (mRNA)
NP_065162 (protein)

NM_001038627 (mRNA)
NP_001033716 (protein)

Location

n/a

Chr 5: 145.13 - 145.22 Mb

Pubmed search

[1]

[2]

SMAD specific E3 ubiquitin protein ligase 1, also known as SMURF1, is a human gene.^[1]

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1.

[edit] Further reading

Wrana JL, Attisano L (2000). "The Smad pathway.". Cytokine Growth Factor Rev. 11 (1-2): 5–13. PMID 10708948.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Zhu H, Kavsak P, Abdollah S, et al. (1999). "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.". Nature 400 (6745): 687–93. doi:10.1038/23293. PMID 10458166.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. PMID 10997877.
Ebisawa T, Fukuchi M, Murakami G, et al. (2001). "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.". J. Biol. Chem. 276 (16): 12477–80. doi:10.1074/jbc.C100008200. PMID 11278251.
Suzuki C, Murakami G, Fukuchi M, et al. (2002). "Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.". J. Biol. Chem. 277 (42): 39919–25. doi:10.1074/jbc.M201901200. PMID 12151385.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tajima Y, Goto K, Yoshida M, et al. (2003). "Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7.". J. Biol. Chem. 278 (12): 10716–21. doi:10.1074/jbc.M212663200. PMID 12519765.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Koinuma D, Shinozaki M, Komuro A, et al. (2004). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.". EMBO J. 22 (24): 6458–70. doi:10.1093/emboj/cdg632. PMID 14657019.
Wang HR, Zhang Y, Ozdamar B, et al. (2003). "Regulation of cell polarity and protrusion formation by targeting RhoA for degradation.". Science 302 (5651): 1775–9. doi:10.1126/science.1090772. PMID 14657501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Asano Y, Ihn H, Yamane K, et al. (2004). "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.". J. Clin. Invest. 113 (2): 253–64. doi:10.1172/JCI200416269. PMID 14722617.
Jin YH, Jeon EJ, Li QL, et al. (2004). "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.". J. Biol. Chem. 279 (28): 29409–17. doi:10.1074/jbc.M313120200. PMID 15138260.
Shearwin-Whyatt LM, Brown DL, Wylie FG, et al. (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.". J. Cell. Sci. 117 (Pt 16): 3679–89. doi:10.1242/jcs.01212. PMID 15252135.
Bryan B, Cai Y, Wrighton K, et al. (2005). "Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth.". FEBS Lett. 579 (5): 1015–9. doi:10.1016/j.febslet.2004.12.074. PMID 15710384.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.