SMPD3

From Wikipedia, the free encyclopedia

Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

Identifiers

SMPD3; FLJ22593; MGC138443; NSMASE2

External IDs

OMIM: 605777 MGI: 1927578 HomoloGene: 10260

Gene ontology
Molecular Function:	• magnesium ion binding • sphingomyelin phosphodiesterase activity • hydrolase activity
Cellular Component:	• Golgi cis cisterna • membrane fraction • Golgi apparatus • membrane • integral to membrane
Biological Process:	• sphingomyelin catabolic process • cell cycle • multicellular organismal development • peptide hormone secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018667 (mRNA)
NP_061137 (protein)

NM_021491 (mRNA)
NP_067466 (protein)

Location

Chr 16: 66.95 - 67.04 Mb

Chr 8: 109.14 - 109.23 Mb

Pubmed search

[1]

[2]

Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II), also known as SMPD3, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II).

[edit] Further reading

Hofmann K, Tomiuk S, Wolff G, Stoffel W (2000). "Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5895-900. PMID 10823942.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443-9. PMID 12417987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Marchesini N, Luberto C, Hannun YA (2003). "Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.". J. Biol. Chem. 278 (16): 13775-83. doi:10.1074/jbc.M212262200. PMID 12566438.
Miura Y, Gotoh E, Nara F, et al. (2004). "Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.". FEBS Lett. 557 (1-3): 288-92. PMID 14741383.
Marchesini N, Osta W, Bielawski J, et al. (2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.". J. Biol. Chem. 279 (24): 25101-11. doi:10.1074/jbc.M313662200. PMID 15051724.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase.". J. Neurosci. 24 (43): 9531-40. doi:10.1523/JNEUROSCI.3085-04.2004. PMID 15509740.
Krut O, Wiegmann K, Kashkar H, et al. (2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein.". J. Biol. Chem. 281 (19): 13784-93. doi:10.1074/jbc.M511306200. PMID 16517606.
Levy M, Castillo SS, Goldkorn T (2006). "nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis.". Biochem. Biophys. Res. Commun. 344 (3): 900-5. doi:10.1016/j.bbrc.2006.04.013. PMID 16631623.
Clarke CJ, Truong TG, Hannun YA (2007). "Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.". J. Biol. Chem. 282 (2): 1384-96. doi:10.1074/jbc.M609216200. PMID 17085432.
Tani M, Hannun YA (2007). "Analysis of membrane topology of neutral sphingomyelinase 2.". FEBS Lett. 581 (7): 1323-8. doi:10.1016/j.febslet.2007.02.046. PMID 17349629.