SMG7

From Wikipedia, the free encyclopedia

Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

PDB rendering based on 1ya0.

Available structures: 1ya0

Identifiers

Symbol(s)

SMG7; C1orf16; EST1C; FLJ23717; KIAA0250; SGA56M; SMG-7

External IDs

MGI: 2682334 HomoloGene: 32235

Gene ontology
Molecular Function:	• protein binding • protein phosphatase 2A binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• mRNA catabolic process, nonsense-mediated decay • mRNA export from nucleus • regulation of dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014837 (mRNA)
NP_055652 (protein)

NM_001005507 (mRNA)
NP_001005507 (protein)

Location

Chr 1: 181.71 - 181.79 Mb

Chr 1: 154.6 - 154.64 Mb

Pubmed search

[1]

[2]

Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), also known as SMG7, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Reichenbach P, Höss M, Azzalin CM, et al. (2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed.". Curr. Biol. 13 (7): 568–74. PMID 12676087.
Snow BE, Erdmann N, Cruickshank J, et al. (2004). "Functional conservation of the telomerase protein Est1p in humans.". Curr. Biol. 13 (8): 698–704. PMID 12699629.
Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.". Mol. Cell 12 (5): 1187–200. PMID 14636577.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Unterholzner L, Izaurralde E (2005). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.". Mol. Cell 16 (4): 587–96. doi:10.1016/j.molcel.2004.10.013. PMID 15546618.
Fukuhara N, Ebert J, Unterholzner L, et al. (2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.". Mol. Cell 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.". Curr. Biol. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.