SMG6

From Wikipedia, the free encyclopedia

Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)

PDB rendering based on 2dok.

Available structures: 2dok, 2hww, 2hwx

Identifiers

Symbol(s)

SMG6; C17orf31; EST1A; KIAA0732; SMG-6

External IDs

MGI: 2144117 HomoloGene: 23024

Gene ontology
Molecular Function:	• DNA binding • protein binding • telomeric DNA binding
Cellular Component:	• chromosome, telomeric region • nucleus • chromosome • telomerase holoenzyme complex • cytoplasm
Biological Process:	• mRNA catabolic process, nonsense-mediated decay • telomere maintenance • mRNA export from nucleus • regulation of dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017575 (mRNA)
NP_060045 (protein)

NM_001002764 (mRNA)
NP_001002764 (protein)

Location

Chr 17: 1.91 - 2.22 Mb

Chr 11: 74.74 - 74.98 Mb

Pubmed search

[1]

[2]

Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans), also known as SMG6, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMG6 Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277-86. PMID 9872452.
Hoff C, Seranski P, Mollenhauer J, et al. (2001). "Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer.". Genomics 70 (1): 26-33. doi:10.1006/geno.2000.6353. PMID 11087658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chiu SY, Serin G, Ohara O, Maquat LE (2003). "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.". RNA 9 (1): 77-87. PMID 12554878.
Reichenbach P, Höss M, Azzalin CM, et al. (2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed.". Curr. Biol. 13 (7): 568-74. PMID 12676087.
Snow BE, Erdmann N, Cruickshank J, et al. (2004). "Functional conservation of the telomerase protein Est1p in humans.". Curr. Biol. 13 (8): 698-704. PMID 12699629.
Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.". Mol. Cell 12 (5): 1187-200. PMID 14636577.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Fukuhara N, Ebert J, Unterholzner L, et al. (2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.". Mol. Cell 17 (4): 537-47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.". Curr. Biol. 16 (4): 433-9. doi:10.1016/j.cub.2006.01.018. PMID 16488880.
Takeshita D, Zenno S, Lee WC, et al. (2006). "Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 7): 656-8. doi:10.1107/S1744309106020057. PMID 16820686.
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (2007). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.". EMBO J. 25 (21): 5117-25. doi:10.1038/sj.emboj.7601377. PMID 17053788.
Takeshita D, Zenno S, Lee WC, et al. (2007). "Crystal structure of the PIN domain of human telomerase-associated protein EST1A.". Proteins 68 (4): 980-9. doi:10.1002/prot.21351. PMID 17557331.