SMG5

From Wikipedia, the free encyclopedia

Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)

PDB rendering based on 2hwy.

Available structures: 2hwy

Identifiers

Symbol(s)

SMG5; EST1B; FLJ34864; KIAA1089; LPTS-RP1; LPTSRP1; RP11-54H19.7; SMG-5

External IDs

MGI: 2447364 HomoloGene: 9095

Gene ontology
Molecular Function:	• protein binding • protein phosphatase 2A binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• mRNA catabolic process, nonsense-mediated decay • mRNA export from nucleus • regulation of dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015327 (mRNA)
NP_056142 (protein)

XM_130930 (mRNA)
XP_130930 (protein)

Location

Chr 1: 154.49 - 154.52 Mb

Chr 3: 88.42 - 88.45 Mb

Pubmed search

[1]

[2]

Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans), also known as SMG5, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197-205. PMID 10470851.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Reichenbach P, Höss M, Azzalin CM, et al. (2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed.". Curr. Biol. 13 (7): 568-74. PMID 12676087.
Snow BE, Erdmann N, Cruickshank J, et al. (2004). "Functional conservation of the telomerase protein Est1p in humans.". Curr. Biol. 13 (8): 698-704. PMID 12699629.
Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.". Mol. Cell 12 (5): 1187-200. PMID 14636577.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Unterholzner L, Izaurralde E (2005). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.". Mol. Cell 16 (4): 587-96. doi:10.1016/j.molcel.2004.10.013. PMID 15546618.
Fukuhara N, Ebert J, Unterholzner L, et al. (2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.". Mol. Cell 17 (4): 537-47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.". Curr. Biol. 16 (4): 433-9. doi:10.1016/j.cub.2006.01.018. PMID 16488880.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Lee H, Sengupta N, Villagra A, et al. (2006). "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.". Mol. Cell. Biol. 26 (14): 5259-69. doi:10.1128/MCB.01971-05. PMID 16809764.
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (2007). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.". EMBO J. 25 (21): 5117-25. doi:10.1038/sj.emboj.7601377. PMID 17053788.