SMC6

From Wikipedia, the free encyclopedia

Structural maintenance of chromosomes 6

Identifiers

SMC6; FLJ22116; FLJ35534; SMC6L1

External IDs

OMIM: 609387 MGI: 1914491 HomoloGene: 41575

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding
Cellular Component:	• intracellular • nucleus • chromosome
Biological Process:	• DNA repair • DNA recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024624 (mRNA)
NP_078900 (protein)

NM_025695 (mRNA)
NP_079971 (protein)

Location

Chr 2: 17.71 - 17.8 Mb

Chr 12: 11.29 - 11.35 Mb

Pubmed search

[1]

[2]

Structural maintenance of chromosomes 6, also known as SMC6, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMC6 structural maintenance of chromosomes 6.

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Taylor EM, Moghraby JS, Lees JH, et al. (2001). "Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.". Mol. Biol. Cell 12 (6): 1583-94. PMID 11408570.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Potts PR, Yu H (2005). "Human MMS21/NSE2 is a SUMO ligase required for DNA repair.". Mol. Cell. Biol. 25 (16): 7021-32. doi:10.1128/MCB.25.16.7021-7032.2005. PMID 16055714.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Potts PR, Porteus MH, Yu H (2006). "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.". EMBO J. 25 (14): 3377-88. doi:10.1038/sj.emboj.7601218. PMID 16810316.
Potts PR, Yu H (2007). "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.". Nat. Struct. Mol. Biol. 14 (7): 581-90. doi:10.1038/nsmb1259. PMID 17589526.