SMC5

From Wikipedia, the free encyclopedia

Structural maintenance of chromosomes 5

Identifiers

SMC5; KIAA0594; SMC5L!; SMC5L1

External IDs

OMIM: 609386 MGI: 2385088 HomoloGene: 41009

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding
Cellular Component:	• nucleus • chromosome
Biological Process:	• DNA repair • DNA recombination

Orthologs

Human

Mouse

Refseq

NM_015110 (mRNA)
NP_055925 (protein)

NM_153808 (mRNA)
NP_722503 (protein)

Location

Chr 9: 72.06 - 72.16 Mb

Chr 19: 23.28 - 23.34 Mb

Pubmed search

[1]

[2]

Structural maintenance of chromosomes 5, also known as SMC5, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMC5 structural maintenance of chromosomes 5.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581.
Taylor EM, Moghraby JS, Lees JH, et al. (2001). "Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.". Mol. Biol. Cell 12 (6): 1583-94. PMID 11408570.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Potts PR, Yu H (2005). "Human MMS21/NSE2 is a SUMO ligase required for DNA repair.". Mol. Cell. Biol. 25 (16): 7021-32. doi:10.1128/MCB.25.16.7021-7032.2005. PMID 16055714.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Potts PR, Porteus MH, Yu H (2006). "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks.". EMBO J. 25 (14): 3377-88. doi:10.1038/sj.emboj.7601218. PMID 16810316.
Potts PR, Yu H (2007). "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.". Nat. Struct. Mol. Biol. 14 (7): 581-90. doi:10.1038/nsmb1259. PMID 17589526.