SMC4

From Wikipedia, the free encyclopedia

Structural maintenance of chromosomes 4

Identifiers

SMC4; CAPC; SMC4L1; hCAP-C

External IDs

OMIM: 605575 MGI: 1917349 HomoloGene: 4015

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • protein heterodimerization activity
Cellular Component:	• condensin complex • nucleus • chromosome
Biological Process:	• DNA metabolic process • chromosome organization and biogenesis (sensu Eukaryota) • cell cycle • mitotic chromosome condensation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001002799 (mRNA)
NP_001002799 (protein)

XM_974335 (mRNA)
XP_979429 (protein)

Location

Chr 3: 161.6 - 161.64 Mb

n/a

Pubmed search

[1]

[2]

Structural maintenance of chromosomes 4, also known as SMC4, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMC4 structural maintenance of chromosomes 4.

[edit] Further reading

Hirano T (2002). "The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair.". Genes Dev. 16 (4): 399–414. doi:10.1101/gad.955102. PMID 11850403.
Ball Jr AR, Yokomori K (2001). "The structural maintenance of chromosomes (SMC) family of proteins in mammals.". Chromosome Res. 9 (2): 85–96. PMID 11321372.
Ham MF, Takakuwa T, Rahadiani N, et al. (2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.". Cancer Sci. 98 (7): 1041–7. doi:10.1111/j.1349-7006.2007.00500.x. PMID 17488335.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMID 15148359.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts.". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
Schmiesing JA, Gregson HC, Zhou S, Yokomori K (2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.". Mol. Cell. Biol. 20 (18): 6996–7006. PMID 10958694.
Nishiwaki T, Daigo Y, Kawasoe T, et al. (1999). "Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family.". J. Hum. Genet. 44 (3): 197–202. PMID 10319587.
Schmiesing JA, Ball AR, Gregson HC, et al. (1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 12906–11. PMID 9789013.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.