SMC3 (gene)

From Wikipedia, the free encyclopedia

Structural maintenance of chromosomes 3

Identifiers

SMC3; BMH; BAM; CSPG6; HCAP; SMC3L1

External IDs

OMIM: 606062 MGI: 1339795 HomoloGene: 3974

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • ATP binding • ATPase activity • dynein binding • protein heterodimerization activity
Cellular Component:	• nuclear chromosome • lateral element • spindle pole • basement membrane • nucleus • cytoplasm • cohesin complex • nuclear matrix
Biological Process:	• DNA repair • cell cycle • mitotic spindle organization and biogenesis • sister chromatid cohesion • mitosis • meiosis • signal transduction • DNA mediated transformation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005445 (mRNA)
NP_005436 (protein)

NM_007790 (mRNA)
NP_031816 (protein)

Location

Chr 10: 112.32 - 112.35 Mb

Chr 19: 53.65 - 53.7 Mb

Pubmed search

[1]

[2]

Structural maintenance of chromosomes 3, also known as SMC3, is a human gene.^[1]

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: SMC3 structural maintenance of chromosomes 3.

[edit] Further reading

Wu RR, Couchman JR (1997). "cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs.". J. Cell Biol. 136 (2): 433–44. PMID 9015313.
Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.". J. Biol. Chem. 273 (12): 6591–4. PMID 9506951.
Gupta K, Anand G, Yin X, et al. (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc.". Oncogene 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857.
Schmiesing JA, Ball AR, Gregson HC, et al. (1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 12906–11. PMID 9789013.
Ghiselli G, Iozzo RV (2000). "Overexpression of bamacan/SMC3 causes transformation.". J. Biol. Chem. 275 (27): 20235–8. doi:10.1074/jbc.C000213200. PMID 10801778.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Sumara I, Vorlaufer E, Gieffers C, et al. (2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase.". J. Cell Biol. 151 (4): 749–62. PMID 11076961.
Revenkova E, Eijpe M, Heyting C, et al. (2001). "Novel meiosis-specific isoform of mammalian SMC1.". Mol. Cell. Biol. 21 (20): 6984–98. doi:10.1128/MCB.21.20.6984-6998.2001. PMID 11564881.
Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly.". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
Kim ST, Xu B, Kastan MB (2002). "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage.". Genes Dev. 16 (5): 560–70. doi:10.1101/gad.970602. PMID 11877376.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
James RD, Schmiesing JA, Peters AH, et al. (2003). "Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice.". Chromosome Res. 10 (7): 549–60. PMID 12498344.
Ghiselli G, Coffee N, Munnery CE, et al. (2003). "The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway.". J. Biol. Chem. 278 (22): 20259–67. doi:10.1074/jbc.M209511200. PMID 12651860.
Lee J, Iwai T, Yokota T, Yamashita M (2004). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis.". J. Cell. Sci. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
Prieto I, Tease C, Pezzi N, et al. (2004). "Cohesin component dynamics during meiotic prophase I in mammalian oocytes.". Chromosome Res. 12 (3): 197–213. PMID 15125634.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Patel CA, Ghiselli G (2006). "Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3.". BMC Cell Biol. 6 (1): 3. doi:10.1186/1471-2121-6-3. PMID 15656913.
Rankin S, Ayad NG, Kirschner MW (2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.". Mol. Cell 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
Khanna H, Hurd TW, Lillo C, et al. (2005). "RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.". J. Biol. Chem. 280 (39): 33580–7. doi:10.1074/jbc.M505827200. PMID 16043481.