SMC2

From Wikipedia, the free encyclopedia

Structural maintenance of chromosomes 2

Identifiers

SMC2; CAP-E; CAPE; FLJ10093; SMC2L1; hCAP-E

External IDs

OMIM: 605576 MGI: 106067 HomoloGene: 4705

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • protein heterodimerization activity
Cellular Component:	• nuclear chromosome • condensin complex • nucleus • chromosome • cytoplasm
Biological Process:	• DNA metabolic process • cell cycle • mitosis • mitotic chromosome condensation • chromosome organization and biogenesis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042550 (mRNA)
NP_001036015 (protein)

NM_008017 (mRNA)
NP_032043 (protein)

Location

Chr 9: 105.9 - 105.94 Mb

Chr 4: 52.46 - 52.51 Mb

Pubmed search

[1]

[2]

Structural maintenance of chromosomes 2, also known as SMC2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMC2 structural maintenance of chromosomes 2.

[edit] Further reading

Ham MF, Takakuwa T, Rahadiani N, et al. (2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.". Cancer Sci. 98 (7): 1041-7. doi:10.1111/j.1349-7006.2007.00500.x. PMID 17488335.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.". Nucleic Acids Res. 32 (9): 2716-29. doi:10.1093/nar/gkh589. PMID 15148359.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Przewloka MR, Pardington PE, Yannone SM, et al. (2003). "In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex.". Mol. Biol. Cell 14 (2): 685-97. doi:10.1091/mbc.E01-11-0117. PMID 12589063.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts.". J. Biol. Chem. 276 (8): 5417-20. doi:10.1074/jbc.C000873200. PMID 11136719.
Schmiesing JA, Gregson HC, Zhou S, Yokomori K (2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.". Mol. Cell. Biol. 20 (18): 6996-7006. PMID 10958694.
Schmiesing JA, Ball AR, Gregson HC, et al. (1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 12906-11. PMID 9789013.