Small ubiquitin-related modifier 1

From Wikipedia, the free encyclopedia

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

PDB rendering based on 1a5r.

Available structures: 1a5r, 1tgz, 1wyw, 1y8r, 1z5s, 2asq, 2bf8, 2g4d, 2io2, 2iy0, 2iy1, 2pe6

Identifiers

Symbol(s)

SUMO1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; SUMO-1; UBL1

External IDs

OMIM: 601912 MGI: 1197010 HomoloGene: 2514

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • nuclear pore
Biological Process:	• DNA repair • protein modification process • ubiquitin cycle • negative regulation of transcription • protein sumoylation • negative regulation of transcription factor activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001005781 (mRNA)
NP_001005781 (protein)

NM_009460 (mRNA)
NP_033486 (protein)

Location

Chr 2: 202.78 - 202.81 Mb

Chr 1: 59.58 - 59.6 Mb

Pubmed search

[1]

[2]

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae), also known as SUMO1, is a human gene.

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.^[1]

[edit] References

^ Entrez Gene: SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae).

[edit] Further reading

Cookson MR (2003). "Pathways to Parkinsonism.". Neuron 37 (1): 7–10. PMID 12526767.
Boddy MN, Howe K, Etkin LD, et al. (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.". Oncogene 13 (5): 971–82. PMID 8806687.
Shen Z, Pardington-Purtymun PE, Comeaux JC, et al. (1997). "UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins.". Genomics 36 (2): 271–9. doi:10.1006/geno.1996.0462. PMID 8812453.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Okura T, Gong L, Kamitani T, et al. (1996). "Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.". J. Immunol. 157 (10): 4277–81. PMID 8906799.
Shen Z, Pardington-Purtymun PE, Comeaux JC, et al. (1997). "Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system.". Genomics 37 (2): 183–6. doi:10.1006/geno.1996.0540. PMID 8921390.
Matunis MJ, Coutavas E, Blobel G (1997). "A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.". J. Cell Biol. 135 (6 Pt 1): 1457–70. PMID 8978815.
Mahajan R, Delphin C, Guan T, et al. (1997). "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.". Cell 88 (1): 97–107. PMID 9019411.
Lapenta V, Chiurazzi P, van der Spek P, et al. (1997). "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.". Genomics 40 (2): 362–6. doi:10.1006/geno.1996.4556. PMID 9119407.
Kamitani T, Nguyen HP, Yeh ET (1997). "Preferential modification of nuclear proteins by a novel ubiquitin-like molecule.". J. Biol. Chem. 272 (22): 14001–4. PMID 9162015.
Mahajan R, Gerace L, Melchior F (1998). "Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association.". J. Cell Biol. 140 (2): 259–70. PMID 9442102.
Howe K, Williamson J, Boddy N, et al. (1998). "The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes.". Genomics 47 (1): 92–100. doi:10.1006/geno.1997.5091. PMID 9465300.
Bayer P, Arndt A, Metzger S, et al. (1998). "Structure determination of the small ubiquitin-related modifier SUMO-1.". J. Mol. Biol. 280 (2): 275–86. doi:10.1006/jmbi.1998.1839. PMID 9654451.
Desterro JM, Rodriguez MS, Hay RT (1998). "SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.". Mol. Cell 2 (2): 233–9. PMID 9734360.
Juo P, Kuo CJ, Yuan J, Blenis J (1998). "Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.". Curr. Biol. 8 (18): 1001–8. PMID 9740801.
Kamitani T, Kito K, Nguyen HP, et al. (1998). "Identification of three major sentrinization sites in PML.". J. Biol. Chem. 273 (41): 26675–82. PMID 9756909.
Duprez E, Saurin AJ, Desterro JM, et al. (1999). "SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.". J. Cell. Sci. 112 ( Pt 3): 381–93. PMID 9885291.
Chen A, Mannen H, Li SS (1999). "Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes.". Biochem. Mol. Biol. Int. 46 (6): 1161–74. PMID 9891849.
Okuma T, Honda R, Ichikawa G, et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.
Liou ML, Liou HC (1999). "The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis.". J. Biol. Chem. 274 (15): 10145–53. PMID 10187798.