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| Small nucleolar SNORD12/SNORD106 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; RNAalifold, Daub J |
| Seed alignment: |
Marantidis E. |
| Avg length: |
86.1 nucleotides |
| Avg identity: |
71% |
|
In molecular biology, the small nucleolar RNAs SNORD106 and SNORD12 (also known as U106 and HBII-99 respectively ) are two related snoRNAs which belongs to the C/D class of small nucleolar RNAs (snoRNAs). Both contain the conserved C (UGAUGA) and D (CUGA) box sequence motifs [1]
Human SNORD12 (HBII-99) is the homologue of mouse snoRNA MBII-99. In humans both HB11-99 and U106 snoRNAs share the same host gene.[2] Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878.[3] U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA.[4] However, these targets do not appear to be methylated and U106 might function as an RNA chaperone during rRNA folding.[2] A similar role has been suggested for the H/ACA snoRNAs U17a and U17b[2]
[edit] References
- ^ Vitali, P; Royo H, Seitz H, Bachellerie JP, Huttenhofer A, Cavaille J (2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Res. 31: 6543–6551. doi:10.1093/nar/gkg849. PMID 14602913.
- ^ a b c Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34: D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
- ^ Huttenhofer, A; Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20: 2943–2953. doi:10.1093/emboj/20.11.2943. PMID 11387227.
- ^ Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109: 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
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