Small nucleolar RNA snoZ7/snoR77

From Wikipedia, the free encyclopedia

Small nucleolar RNA snoZ7/snoR77

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD
Seed alignment:	http://bioinf.scri.sari.ac.uk/cgi-bin/plant_snorna/home
Avg length:	80.2 nucleotides
Avg identity:	82%

The snoRNA snoZ7/snoZ77 family contains related non-coding RNA molecules that are members of the C/D class of snoRNA which contain the C box motif (UGAUGA) and the D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1]^[2]. snoZ7 RNA guides the methylation of 25S rRNA position A1372, whereas SnoR77Y guides the methylation of 18S rRNA at position U580. This family of snoRNAs has been found in plant species such as Arabidopsis thaliana.

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Marker, C; Zemann A, Terhorst T, Kiefmann M, Kastenmayer JP, Green P, Bachellerie JP, Brosius J, Huttenhofer A (2002). "Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana". Curr Biol 12: 2002–2013. doi:10.1016/S0960-9822(02)01304-0. PMID 12477388.