Small nucleolar RNA snoR9
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Small nucleolar RNA snoR9 | ||||||||||
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snoR9 is a non-coding RNA (ncRNA) which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.
R9 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1].
This snoRNA was identified in a computational search for GC-rich regions in the AT-rich genomes of hyperthermophiles [2]. This snoRNA is not related to the plant snoRNA snoR9.
[edit] References
- ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol. Cell. Biol. 22 (19): 6663–8. PMID 12215523.
- ^ Klein RJ, Misulovin Z, Eddy SR (2002). "Noncoding RNA genes identified in AT-rich hyperthermophiles". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7542–7. doi: . PMID 12032319.