Small nucleolar RNA snoM1

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Small nucleolar RNA snoM1

Type:	Gene; snRNA; guide; HACA-box;
2° structure:	Predicted; ILM: Moxon SJ
Seed alignment:	Moxon SJ
Avg length:	99.6 nucleotides
Avg identity:	91%

Small nucleolar RNA snoM1 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

M1 is a predicted to belong to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines ^[1]. snoM1 seems to be found exclusively in Drosophila species.

[edit] References

^ Kiss AM, Jády BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol. Cell. Biol. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.

[2] Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109: 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.