From Wikipedia, the free encyclopedia
| Small nucleolar RNA snR60/Z15/Z230/Z193/J17 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; Griffiths-Jones S |
| Seed alignment: |
Griffiths-Jones S |
| Avg length: |
93.4 nucleotides |
| Avg identity: |
64% |
|
snoRNA snR60 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1]. snoRNA snR60 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome [2], subsequent experimental screens discoveres plant homoloues Z15, Z230, Z193 and J17 [3].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Lowe TM, Eddy SR (1999). "A computational screen for methylation guide snoRNAs in yeast". Science 283 (5405): 1168–71. PMID 10024243.
- ^ Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. PMID 12736310.
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