Small nucleolar RNA snR55/Z10

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Small nucleolar RNA snR55/Z10
Template:Abbreviation
Type: Gene; snRNA; guide; CD-box;
2° structure: Predicted; Griffiths-Jones S
Seed alignment: Moxon SJ
Avg length: 88.4 nucleotides
Avg identity: 74%

Small nucleolar RNA snR55/Z10 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis of other small nuclear RNAs (snRNAs). These small nucleolar RNAs (snoRNAs) are modifiying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

snoRNA snR55 was identified in (Schizosaccharomyces pombe) and has also been called snoRNA Z10 [1]. This snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[2].

This predicted snoRNA does not appear to have the C/D box snoRNA terminal stem structure.

[edit] References

  1. ^ Lowe TM, Eddy SR (1999). "A computational screen for methylation guide snoRNAs in yeast". Science 283 (5405): 1168–71. PMID 10024243. 
  2. ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523. 

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