Small nucleolar RNA snR54

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Small nucleolar RNA snR54

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; Griffiths-Jones S
Seed alignment:	Moxon SJ
Avg length:	81.8 nucleotides
Avg identity:	76%

snR54 is a non-coding RNA that is a member of the C/D class of snoRNA which contain the C box motif (UGAUGA) and D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA was first identified by a computational screen followed by experimental verification [1]. This RNA guides the 2'-O-methylation of 18S rRNA. In yeast this snoRNA is found to reside in an intron of the IMD4 gene.

[edit] Species distribution

This snoRNA has been identified in both yeasts and D. melanogaster.

[edit] References

[1] Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109: 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
[2] Lowe, TM; Eddy SR (1999). "A computational screen for methylation guide snoRNAs in yeast". Science 283: 1168–1171. doi:10.1126/science.283.5405.1168. PMID 10024243.