Small nucleolar RNA Z17

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Small nucleolar RNA Z17

Type:	Gene; snRNA; guide; CD-box;
2° structure:	Predicted; PFOLD
Seed alignment:	http://ribosome.miyazaki-med.ac.jp/
Avg length:	71.8 nucleotides
Avg identity:	79%

snoRNA Z17 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z17 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs^[1]. snoRNA Z17B is predicted to guide the 2'-O-ribose methylation of 18S rRNA at position U121^[2]. Two forms of this snoRNA are found in the intron of the ribosomal protein L23a gene.

[edit] References

^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-ribose methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
^ Maden BE (1990). "The numerous modified nucleotides in eukaryotic ribosomal RNA". Prog. Nucleic Acid Res. Mol. Biol. 39: 241–303. PMID 2247610.