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| Small nucleolar RNA Z161/Z228 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; PFOLD; Moxon SJ |
| Seed alignment: |
Moxon SJ |
| Avg length: |
92.2 nucleotides |
| Avg identity: |
82% |
|
Small nucleolar RNA Z161 (homologous to snoRNA Z228) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z161 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1] [2]. Plant snoRNA Z161 was identified in a screen of Oryza sativa [3].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109: 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
- ^ Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. PMID 12736310.
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