From Wikipedia, the free encyclopedia
| Small nucleolar RNA Z13/snr52 |
 |
| Type: |
Gene; snRNA; guide; CD-box; |
| 2° structure: |
Predicted; PFOLD; Moxon SJ |
| Seed alignment: |
Moxon SJ |
| Avg length: |
95.9 nucleotides |
| Avg identity: |
74% |
|
Small nucleolar RNA snR52 (homologous to Z13) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z13 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1]. snoRNA snR52 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome [2], subsequent work identified Z13 in Schizosaccharomyces pombe. Further experiments have shown that snR52 is transcribed by RNA polymerase III [3] [4].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22: 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.
- ^ Lowe TM, Eddy SR (1999). "A computational screen for methylation guide snoRNAs in yeast". Science 283 (5405): 1168–71. PMID 10024243.
- ^ Harismendy O, Gendrel CG, Soularue P, et al (2003). "Genome-wide location of yeast RNA polymerase III transcription machinery". EMBO J. 22 (18): 4738–47. doi:10.1093/emboj/cdg466. PMID 12970186.
- ^ Marck C, Kachouri-Lafond R, Lafontaine I, Westhof E, Dujon B, Grosjean H (2006). "The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications". Nucleic Acids Res. 34 (6): 1816–35. doi:10.1093/nar/gkl085. PMID 16600899.
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